Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

Supported by National Institutes of Health (NIH) grants R01HL105704 (to Dr. Chiu), K08NS096117 (to Dr. Wilson), and K23AI28069 (to Dr. Messacar), a University of California Center for Accelerated Innovation grant funded by NIH grant U54HL119893 and NIH–National Center for Advancing Translational Sciences University of California, San Francisco–Clinical and Translational Science Institute grant UL1TR000004 (to Dr. Chiu), a grant from the California Initiative to Advance Precision Medicine (to Dr. Chiu, Ms. Sample, Ms. Zorn, Mr. Federman, Mr. Stryke, Drs. Fulton and Naccache, Mr. Murkey, Drs. Vespa, Humphries, and Klausner, Ms. Memar, Ms. Ocampo, and Drs. Polage, Wilson, and Miller), a grant from the Chan Zuckerberg Biohub (to Dr. DeRisi), a grant from the Charles and Helen Schwab Foundation (to Drs. Chiu and Miller), a grant from the George and Judy Marcus Innovation Fund (to Drs. Chiu and Miller), an endowment from the Rachleff family (to Dr. Wilson), and a grant from the Sandler and William K. Bowes, Jr., Foundations (to Dr. Chiu, Ms. Zorn, Ms. Sample, and Drs. Wilson, Gelfand, Fulton, Miller, Chow, and DeRisi).

Disclosure forms provided by the authors are available with the full text of this article at

Dr. Wilson and Ms. Sample contributed equally to this article.

We thank Danielle Ingebrigtsen, Walter Lorizio, Tiffany Kwak, Becky Fung, and Lydia Dang at the UCSF Clinical Microbiology Laboratory for their efforts in running the metagenomic next-generation sequencing assay; Herb Sandler, William Bowes, Charles and Helen Schwab, and George and Judy Marcus for their encouragement; and the patients and their families for their participation in this study.

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